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This Department of Health and Human Services grant aims to establish Disease Study Sites (DSS) as part of a collaborative effort to utilize multi-omic technologies in investigating health and disease across diverse populations. The DSS, in conjunction with Omics Production Centers and the Data Analysis and Coordination Center, will focus on integrating multi-omics with phenotypic and environmental data to detect molecular profiles associated with health and disease. The grant seeks to develop data harmonization methods, analysis techniques, and create a comprehensive dataset accessible to researchers. Each DSS will propose a study on a specific disease area to identify associations, changes over time, and contribute to protocol development and data analysis. Deadline for application submission is November 18, 2022.
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Opportunity ID: 343373
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | RFA-HG-22-008 |
| Funding Opportunity Title:: | Multi-Omics for Health and Disease – Disease Study Sites (U01 Clinical Trial Optional) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Education |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 1 |
| Posted Date:: | Sep 07, 2022 |
| Last Updated Date:: | Sep 07, 2022 |
| Original Closing Date for Applications:: | Nov 18, 2022 |
| Current Closing Date for Applications:: | Nov 18, 2022 |
| Archive Date:: | Dec 24, 2022 |
| Estimated Total Program Funding:: | |
| Award Ceiling:: | $500,000 |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | The goal of this Funding Opportunity Announcement (FOA) is to establish Disease Study Sites (DSS) that will be part of a collaborative initiative to advance the application of multi-omic technologies to study health and disease in diverse populations. Together with the Omics Production Centers (RFA-HG-22-009) and the Data Analysis and Coordination Center (RFA-HG-22-010), the Disease Study Sites will leverage clinical conditions where multi-omic approaches are expected to be most informative to: 1) explore the use of multi-omics, integrated with phenotypic and environmental exposure data, including social determinants of health (SDOH), to detect and assess molecular profiles associated with healthy and disease states; 2) develop generalizable data harmonization, integration, and analysis methods, as well as best practices and standards for the optimal application of multi-omics; and 3) create a multi-dimensional dataset that is available to the research community. Each DSS will be primarily responsible for proposing a study focused on a disease area for which integrative multi-omics could be used to define associations with healthy and disease states and to detect changes over time. Each DSS will utilize effective strategies to enroll and consent participants, collect phenotypic and environmental exposure data, collect samples and measures over time, and contribute to consortium-wide protocol development, data analysis, methods development, and the production of the multi-dimensional dataset. While this program may provide some insights into disease etiology, its primary goal is to validate and enhance generalizable multi-omic approaches to identify meaningful biological changes related to health and disease. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 1 | Sep 07, 2022 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | |
| Competition ID: | FORMS-G |
| Competition Title: | Use for due dates on or after January 25, 2022 |
| Opportunity Package ID: | PKG00276656 |
| Opening Date: | Oct 18, 2022 |
| Closing Date: | Nov 18, 2022 |
| Agency Contact Information:: | eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V5.0] PHS 398 Cover Page Supplement [V5.0] Research And Related Other Project Information [V1.4] Project/Performance Site Location(s) [V4.0] Research and Related Senior/Key Person Profile (Expanded) [V4.0] PHS 398 Research Plan [V4.0] PHS Human Subjects and Clinical Trials Information [V3.0] |
| optional_forms |
Research & Related Budget [V3.0] R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V3.0] PHS 398 Modular Budget [V1.2] PHS Assignment Request Form [V3.0] |
Package No: 2
| Assistance Listings: | |
| Competition ID: | FORMS-H |
| Competition Title: | Use for due dates on or after January 25, 2023 |
| Opportunity Package ID: | PKG00277983 |
| Opening Date: | Nov 04, 2022 |
| Closing Date: | Nov 18, 2022 |
| Agency Contact Information:: | eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V5.0] PHS 398 Cover Page Supplement [V5.0] Research And Related Other Project Information [V1.4] Project/Performance Site Location(s) [V4.0] Research and Related Senior/Key Person Profile (Expanded) [V4.0] PHS 398 Research Plan [V5.0] PHS Human Subjects and Clinical Trials Information [V3.0] |
| optional_forms |
Research & Related Budget [V3.0] R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V3.0] PHS 398 Modular Budget [V1.2] PHS Assignment Request Form [V3.0] |
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| FORMS-G | Use for due dates on or after January 25, 2022 | PKG00276656 | Oct 18, 2022 | Nov 18, 2022 | View | eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ | Organization Applicants |
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| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| FORMS-H | Use for due dates on or after January 25, 2023 | PKG00277983 | Nov 04, 2022 | Nov 18, 2022 | View | eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ | Organization Applicants |
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