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The National Institute of Neurological Disorders and Stroke (NINDS) is offering a grant to support preclinical development and testing of therapies for neurological disorders. This program aims to accelerate the translation of basic research findings into potential therapeutic candidates for clinical trials. The grants include Phase I and II SBIR cooperative agreements and focus on projects with therapeutic leads and in vivo proof of concept. Funding excludes clinical and basic research, focusing solely on therapeutic development activities. NINDS staff are actively involved in project planning and monitoring progress, with opportunities for Fast-Track applications and IND/IDE submission readiness by the project end. Deadline: Jan 07, 2013.
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Opportunity ID: 112217
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | PAR-11-296 |
| Funding Opportunity Title:: | NINDS Cooperative Program in Translational Research Small Business Awards (U44) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Health |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 93.853 — Extramural Research Programs in the Neurosciences and Neurological Disorders |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 2 |
| Posted Date:: | Aug 08, 2011 |
| Last Updated Date:: | Apr 10, 2012 |
| Original Closing Date for Applications:: | Sep 07, 2012 |
| Current Closing Date for Applications:: | Jan 07, 2013 |
| Archive Date:: | Feb 07, 2013 |
| Estimated Total Program Funding:: | |
| Award Ceiling:: | $1,000,000 |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Small businesses |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Only United States small business concerns (SBCs) are eligible to submit applications for this opportunity. A small business concern is one that, at the time of award of Phase I and Phase II, meets all of the following criteria: 1. Is organized for profit, with a place of business located in the United States, which operates primarily within the United States or which makes a significant contribution to the United States economy through payment of taxes or use of American products, materials or labor; 2. Is in the legal form of an individual proprietorship, partnership, limited liability company, corporation, joint venture, association, trust or cooperative, except that where the form is a joint venture, there can be no more than 49 percent participation by foreign business entities in the joint venture; 3. Is at least 51 percent owned and controlled by one or more individuals who are citizens of, or permanent resident aliens in, the United States, or it must be a for-profit business concern that is at least 51 percent owned and controlled by another for-profit business concern that is at least 51 percent owned and controlled by one or more individuals who are citizens of, or permanent resident aliens in, the United States, except in the case of a joint venture, where each entity to the venture must be 51 percent owned and controlled by one or more individuals who are citizens of, or permanent resident aliens in, the United States; and; 4. Has, including its affiliates, not more than 500 employees. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | The goal of this funding opportunity announcement (FOA) is to support preclinical development and testing of new therapies for neurological disorders. The program will facilitate encouragementation, development, and review of therapy-directed projects to accelerate the translation of basic research discoveries into therapeutic candidates for clinical testing. Phase II and Fast-Track SBIR cooperative agreements are supported under the program. Phase I, as part of a Fast-Track, supports preliminary steps in the process for the preclinical development of therapeutics. To be eligible for Phase II support, either based on a previously successful Phase I or as part of a Fast-Track, projects must include therapeutic leads and in vivo proof of concept on efficacy. Phase II supports preclinical optimization and testing of the leads, and projects must be sufficiently advanced that an Investigational New Drug (IND) or Investigational Device Exemption (IDE) application to the Food and Drug Administration (FDA) can be submitted by the end of the project period. Phase II cannot support early-stage therapeutic discovery activities such as screening. The program scope excludes clinical research, basic research, and studies of disease mechanism. The scope includes only therapy development activities, so development of diagnostics, biomarkers, or rehabilitation strategies cannot be supported. This is a milestone-driven SBIR cooperative agreement program involving participation of NINDS staff in the development of the project plan and monitoring of research progress. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 2 | Modified Archive Date based on new Expiration Date of January 8, 2013. | Apr 10, 2012 |
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | 93.853 |
| Competition ID: | ADOBE-FORMS-B2 |
| Competition Title: | Adobe-Forms-B2 |
| Opportunity Package ID: | PKG00070070 |
| Opening Date: | Nov 05, 2011 |
| Closing Date: | Jan 07, 2013 |
| Agency Contact Information:: | Grants Info |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] Research & Related Budget [V1.1] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3] SBIR/STTR_Information [V1.1] |
| optional_forms |
R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS Cover Letter [V1.2] |
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Agency Contact Information: | Who Can Apply: |
|---|---|---|---|---|---|---|---|---|
| 93.853 | ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00070070 | Nov 05, 2011 | Jan 07, 2013 | View | Grants Info | Organization Applicants |
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