The National Heart, Lung, and Blood Institute (NHLBI) is offering grants for a study to characterize the lung microbiome in HIV-infected individuals and controls. This grant aims to identify bacteria and other organisms in the lung, nasal, and oropharyngeal cavities using molecular techniques. Researchers will analyze how changes in the microbiota relate to HIV lung disease progression and complications. The grant includes funding for Clinical/Sequencing research sites and a Data Coordinating Center. Collaboration with other funded projects is encouraged. Application deadline is March 25, 2009.
Opportunity ID: 43587
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-HL-09-006 |
| Funding Opportunity Title: | Microbiome of the Lung and Respiratory Tract in HIV-Infected Individuals and HIV-Uninfected Controls (U01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Cooperative Agreement |
| Category of Funding Activity: | Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.838 — Lung Diseases Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 04, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Mar 25, 2009 |
| Current Closing Date for Applications: | Mar 25, 2009 |
| Archive Date: | Apr 25, 2009 |
| Estimated Total Program Funding: | $4,000,000 |
| Award Ceiling: | $525,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Special district governments State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts County governments City or township governments |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose.The National Heart, Lung, and Blood Institute (NHLBI) solicits grant applications under this Funding Opportunity Announcement (FOA) to characterize the microbiome of the lung (the airways and airspaces below the glottis and the lung parenchyma) alone or in combination with the nasal and/or oropharyngeal cavities in HIV-infected individuals and matched HIV-uninfected controls, including normal healthy controls, using molecular techniques to identify bacteria and if possible other organisms, e.g., viruses, cell-wall deficient organisms, protozoa, and fungi. Investigators should use high-throughput technology platforms to create a data set of sufficient quality and depth to allow analysis of how changes of microbiota relate to HIV lung disease progression/complications.These data will be used to examine the impact of changes in the respiratory microbiome on the pathogenesis and progression of HIV disease, on HIV-related respiratory complications, and the effects of anti-HIV therapies.
The National Heart, Lung, and Blood Institute (NHLBI) invites applications for four Clinical/Sequencing research sites and one supporting Data Coordinating Center (DCC).Each application for a clinical/sequencing research site should propose approaches to characterize the lung microbiome and applicants are encouraged to include at least one hypothesis-driven mechanistic aim.Applicants must agree to collaborate with the other Clinical/Sequencing sites, the DCC, and projects funded under the Roadmap HMP program on overlapping areas of interest.Inclusion of the nasal and or pharyngeal cavities is optional.The Lung HIV Microbiome Program is designed to promote cooperation and coordination, facilitate scientific exchange, and leverage resources. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-006.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
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