This grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Cancer Institute (NCI), and Office of Dietary Supplements (ODS) seeks to fund research into the molecular and biochemical mechanisms underlying alcohol-induced cancers in organs like the oral cavity, liver, and breast. Utilizing advanced technologies, the research will focus on factors such as acetaldehyde, CYP2E1, VEGF, immune function, and metabolism of essential nutrients. With a maximum budget of $275,000 over a 2-year period, this grant encourages applications from a diverse range of organizations and individuals, emphasizing inclusivity for underrepresented groups in research. Multiple applications are allowed if each project is scientifically unique.
Opportunity ID: 43671
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-270 |
| Funding Opportunity Title: | Mechanisms of Alcohol-Associated Cancers (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | May 07, 2009 Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Jun 07, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments City or township governments Independent school districts Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Native American tribal governments (Federally recognized) County governments Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government are eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Cancer Institute (NCI), and Office of Dietary Supplements (ODS) invite research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms by which chronic alcohol consumption leads to the development of cancers of various organs such as oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast. This includes investigating roles of various factors such as acetaldehyde, cytochrome P450 2E1 (CYP2E1), vascular endothelial growth factor (VEGF), impaired immune function, and alcohol-induced impaired metabolism of s-adenosylmethionine (SAMe), folate, betaine, iron, and vitamin A.. -This Funding Opportunity Announcement (FOA) will use the NIH R21 mechanism. -This funding opportunity will utilize the exploratory/developmental (R21) grant mechanism, but will be run in parallel with a program announcement of identical scientific scope (PA-06-269) that will utilize the traditional research project grant (R01). -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: Applicants may request a project period of up to 2 years with a combined budget for direct costs of up to $275,000 for the 2 year period. For example, an applicant may request $100,000 in the first year and $175,000 in the second year. The request should be tailored to the needs of the project. Normally, no more than $200,000 may be requested in any single year. -Eligible Organizations: Domestic or foreign, for-profit or non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state and local governments; eligible agencies of the federal government, and faith-based or community-based organizations. -Eligible Project Directors/Principal Investigators (PDs/PIs): Any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. -Applicants may submit more than one application, provided they are scientifically distinct. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-270.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Archive Date has been updated due to Expiration/Closing Date change. | – | |
| Dec 05, 2008 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-270 |
| Funding Opportunity Title: | Mechanisms of Alcohol-Associated Cancers (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | May 07, 2009 Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Jun 07, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Special district governments City or township governments Independent school districts Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Native American tribal governments (Federally recognized) County governments Public and State controlled institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government are eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Cancer Institute (NCI), and Office of Dietary Supplements (ODS) invite research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms by which chronic alcohol consumption leads to the development of cancers of various organs such as oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast. This includes investigating roles of various factors such as acetaldehyde, cytochrome P450 2E1 (CYP2E1), vascular endothelial growth factor (VEGF), impaired immune function, and alcohol-induced impaired metabolism of s-adenosylmethionine (SAMe), folate, betaine, iron, and vitamin A.. -This Funding Opportunity Announcement (FOA) will use the NIH R21 mechanism. -This funding opportunity will utilize the exploratory/developmental (R21) grant mechanism, but will be run in parallel with a program announcement of identical scientific scope (PA-06-269) that will utilize the traditional research project grant (R01). -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: Applicants may request a project period of up to 2 years with a combined budget for direct costs of up to $275,000 for the 2 year period. For example, an applicant may request $100,000 in the first year and $175,000 in the second year. The request should be tailored to the needs of the project. Normally, no more than $200,000 may be requested in any single year. -Eligible Organizations: Domestic or foreign, for-profit or non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state and local governments; eligible agencies of the federal government, and faith-based or community-based organizations. -Eligible Project Directors/Principal Investigators (PDs/PIs): Any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. -Applicants may submit more than one application, provided they are scientifically distinct. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-270.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-270 |
| Funding Opportunity Title: | Mechanisms of Alcohol-Associated Cancers (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Apr 01, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | State governments Public housing authorities/Indian housing authorities Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Special district governments For profit organizations other than small businesses City or township governments County governments |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government are eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Cancer Institute (NCI), and Office of Dietary Supplements (ODS) invite research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms by which chronic alcohol consumption leads to the development of cancers of various organs such as oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast. This includes investigating roles of various factors such as acetaldehyde, cytochrome P450 2E1 (CYP2E1), vascular endothelial growth factor (VEGF), impaired immune function, and alcohol-induced impaired metabolism of s-adenosylmethionine (SAMe), folate, betaine, iron, and vitamin A.. -This Funding Opportunity Announcement (FOA) will use the NIH R21 mechanism. -This funding opportunity will utilize the exploratory/developmental (R21) grant mechanism, but will be run in parallel with a program announcement of identical scientific scope (PA-06-269) that will utilize the traditional research project grant (R01). -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Project Period and Award Levels: Applicants may request a project period of up to 2 years with a combined budget for direct costs of up to $275,000 for the 2 year period. For example, an applicant may request $100,000 in the first year and $175,000 in the second year. The request should be tailored to the needs of the project. Normally, no more than $200,000 may be requested in any single year. -Eligible Organizations: Domestic or foreign, for-profit or non-profit organizations, public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state and local governments; eligible agencies of the federal government, and faith-based or community-based organizations. -Eligible Project Directors/Principal Investigators (PDs/PIs): Any individual with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. -Applicants may submit more than one application, provided they are scientifically distinct. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-270.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009018 | Dec 05, 2008 | May 07, 2009 | View |
Package 1
Mandatory forms
43671 RR_SF424-1.1.pdf
43671 RR_OtherProjectInfo-1.1.pdf
43671 RR_PerformanceSite-1.1.pdf
43671 PHS398_CoverPageSupplement-1.1.pdf
43671 PHS398_ResearchPlan-1.1.pdf
43671 PHS398_Checklist-1.1.pdf
Optional forms
43671 PHS398_CoverLetter-1.1.pdf
43671 PHS398_ModularBudget-1.1.pdf
43671 RR_Budget-1.1.pdf
43671 RR_SubawardBudget-1.2.pdf
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