NIAAA and NIDDK invite researchers to explore the impact of diet and dietary factors on epigenetic processes in cancer prevention. This funding opportunity supports investigations into how bioactive food components and chronic alcohol consumption affect DNA methylation and cancer development. Emphasis is placed on collaborations between nutrition and epigenetics experts. NIAAA seeks studies on the effects of alcohol consumption on SAM, betaine, and folate levels, while NIDDK focuses on gastrointestinal conditions. This grant utilizes the NIH R21 mechanism with a 2-year duration and funding up to $275,000. Open to various organizations and encourages applications from diverse backgrounds and abilities.
Opportunity ID: 43703
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-413 |
| Funding Opportunity Title: | Diet, Epigenetic Events, and Cancer Prevention (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Oct 02, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | For profit organizations other than small businesses City or township governments Special district governments Public and State controlled institutions of higher education Private institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this initiative is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. NIAAA is specifically interested in receiving applications that examine the impact(s) of chronic alcohol consumption on levels of SAM, betaine, and folate, and possible associations with DNA methylation and cancer. NIDDK is particularly interested in receiving applications that address normal and neoplastic conditions focusing on the impact of epigenetics on cell division, differentiation, and/or apoptosis in the gastrointestinal (GI) tract and related organs. -This FOA utilizes the NIH exploratory/developmental (R21) grant mechanism and runs in parallel with two other FOAs of identical scientific scope, one being PA-06-414, which solicits applications using the NIH Small Grant (R03) award mechanism, and the other being PA-06-412 which solicits applications using the NIH Research Project Grant (R01) award mechanism. -Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications; therefore, the anticipated number of awards is not known. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -The total project period for an application submitted in response to this funding opportunity may not exceed 2 years. Direct costs are limited to $275,000 over an R21 2-year period, with no more than $200,000 in direct costs allowed in any single year (note that consortium [third party] facilities and administrative costs are not included in the direct cost limitation). -Eligible organizations include: for-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals and laboratories; units of State and local governments; eligible agencies of the Federal government; domestic or foreign institutions/organizations; faith-based or community-based organizations; Indian/Native American Tribal Governments (Federally Recognized); Indian/Native American Tribal Governments (Other than Federally Recognized); and Indian/Native American Tribally Designated Organizations. -Eligible Project Directors/Principal Investigators (PDs/PIs) include any individual from the institution with the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -Applicants may submit more than one application, provided each application is scientifically distinct. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-413.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009051 | Dec 05, 2008 | Sep 07, 2009 | View |
Package 1
Mandatory forms
43703 RR_SF424-1.1.pdf
43703 RR_OtherProjectInfo-1.1.pdf
43703 RR_PerformanceSite-1.1.pdf
43703 PHS398_CoverPageSupplement-1.1.pdf
43703 PHS398_ResearchPlan-1.1.pdf
43703 PHS398_Checklist-1.1.pdf
Optional forms
43703 PHS398_CoverLetter-1.1.pdf
43703 PHS398_ModularBudget-1.1.pdf
43703 RR_Budget-1.1.pdf
43703 RR_SubawardBudget-1.2.pdf
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