NIAAA and NIDDK are offering grants for research on how diet impacts DNA methylation and epigenetic processes in cancer prevention, including effects of chronic alcohol consumption. The grants aim to foster collaborations between nutrition and epigenetic experts, focusing on bioactive food components and key epigenetic events in cancer processes. The R03 grant mechanism supports various projects such as pilot studies and development of research methodology, with budgets of up to $50,000 per year for 2 years. Eligible organizations and individuals are encouraged to apply, with opportunities for multiple submissions. The grants seek to advance understanding of the linkages between diet, epigenetics, and cancer incidences/behaviors.
Opportunity ID: 43704
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-414 |
| Funding Opportunity Title: | Diet, Epigenetic Events, and Cancer Prevention (R03) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Oct 02, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $50,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education County governments State governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Independent school districts Special district governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Investigators wishing to apply for an R03 grant should be aware that not all NIH Institutes and Centers (ICs) accept investigator-initiated R03 applications and that the different NIH ICs may have specific purposes for which they use this funding mechanism. Therefore, all investigators should consult the R03 web site at http://grants.nih.gov/grants/funding/r03.htm as well as the NIH IC staff listed on this web site to determine if an R03 application is appropriate. Information related to the use of R03 awards by NIH ICs that do not participate in this FOA is also listed on the R03 web site. Additional information about special initiatives involving R03 awards can be found by searching the NIH Guide for Grants and Contracts at http://grants.nih.gov/grants/guide/index.html#search, by examining NIH IC web sites, and by consulting with NIH staff. All investigator-initiated small grant R03 applications described in this FOA will be assigned to the NIH ICs according to standard PHS referral guidelines and specific program interests. Applicants may submit more than one application, provided each application is scientifically distinct. Small grant support may not be used for thesis or dissertation research. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | The aim of this funding opportunity announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. NIAAA is specifically interested in receiving applications that examine the impact(s) of chronic alcohol consumption on levels of SAM, betaine, and folate, and possible associations with DNA methylation and cancer. NIDDK is particularly interested in receiving applications that address normal and neoplastic conditions focusing on the impact of epigenetics on cell division, differentiation, and/or apoptosis in the GI tract and related organs. -This FOA utilizes the NIH Small Grant (R03) mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-412, which solicits applications under the NIH Research Project Grant (R01) mechanism, and PA-06-413, which solicits applications under the NIH Exploratory/Developmental Grant (R21) award mechanism. -The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. -The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources. The R03 is not renewable. -Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications; therefore, the anticipated number of awards is not known. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. -Budgets for direct costs of up to $50,000 per year and a project duration of up to 2 years may be requested for a maximum of $100,000 direct costs over a 2-year project period (note that consortium [third party] facilities and administrative costs are not included in the direct cost limitation). -Eligible organizations include: for-profit organizations; non-profit organizations; public or private institutions, such as universities, colleges, hospitals and laboratories; units of State and local governments; eligible agencies of the Federal government; domestic or foreign institutions/organizations; faith-based or community-based organizations; Indian/Native American Tribal Governments (Federally Recognized); Indian/Native American Tribal Governments (Other than Federally Recognized); and Indian/Native American Tribally Designated Organizations. -Eligible Project Directors/Principal Investigators (PDs/PIs) include any individuals from the applicant institutions who have the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. -Applicants may submit more than one application, provided each application is scientifically distinct. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-414.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009052 | Dec 05, 2008 | Sep 07, 2009 | View |
Package 1
Mandatory forms
43704 RR_SF424-1.1.pdf
43704 RR_OtherProjectInfo-1.1.pdf
43704 RR_PerformanceSite-1.1.pdf
43704 PHS398_CoverPageSupplement-1.1.pdf
43704 PHS398_ResearchPlan-1.1.pdf
43704 PHS398_Checklist-1.1.pdf
Optional forms
43704 PHS398_CoverLetter-1.1.pdf
43704 PHS398_ModularBudget-1.1.pdf
43704 RR_Budget-1.1.pdf
43704 RR_SubawardBudget-1.2.pdf
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