This funding opportunity from the National Cancer Institute aims to support research investigating the role of dietary components in enhancing the tumoricidal activity of natural killer (NK) cells for cancer prevention. Projects should focus on determining the minimum quantity and duration of exposure to specific dietary components to modulate NK cell activity and the underlying mechanisms. Research must involve animal and/or human studies and prioritize in vivo investigations. The grants will be awarded through the NIH R01 grant mechanism. Applications are due by May 07, 2011
Opportunity ID: 44067
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-08-131 |
| Funding Opportunity Title: | Enhancing Tumoricidal Activity of Natural Killer (NK) Cells by Dietary Components for Cancer Prevention (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 07, 2011 |
| Current Closing Date for Applications: | May 07, 2011 |
| Archive Date: | Jun 07, 2011 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility: |
Other Eligible Applicants include the following: Eligible Agencies of the Federal Government Faith-based or Community-based Organizations Non-domestic (non-U.S.) Entities (Foreign Organizations) Regional Organizations U.S. Territory or Possession |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), is designed to stimulate research efforts aimed at establishing the physiological significance of dietary components in modulating the tumoricidal cell activity of natural killer (NK) cells for cancer prevention. The focus of research projects proposed in response to this FOA should be on defining the minimum quantity and duration of exposure to specific dietary components to modulate tumoricidal cell activity of NK cells for cancer prevention and the underlying mechanism(s) accounting for this response. Proposed projects must include animal and/or human investigations to be considered responsive to this announcement. Highly purified populations of immune cells, specific tumor cells such as RMA-S that lack class I MHC expression, target cell-free system, or single-cell assays may be used to define the molecular basis for the diet-induced changes in tumoricidal activity. However, the in vitro studies are only to be used to support in vivo studies and should not constitute the primary focus of the application. Molecular targets for food components may be examined at the sites of the tumoricidal cell receptors and cancer cell specific ligands, the output of tumoricidal cytokines (e.g., IFN-g), and the release of lytic granules such as a granulysin, perforin, and serine proteases (granzymes). -Mechanism of Support. This FOA will utilize the NIH research project R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-132, that solicits applications for exploratory, pilot projects under the NIH R21 grant mechanism. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-08-131.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00014768 | Dec 21, 2009 | May 07, 2011 | View | |
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009415 | Dec 05, 2008 | Feb 20, 2010 | View |
Package 1
Mandatory forms
44067 RR_SF424_1_2-1.2.pdf
44067 PerformanceSite_1_3-1.3.pdf
44067 RR_OtherProjectInfo_1_2-1.2.pdf
44067 RR_KeyPersonExpanded_1_2-1.2.pdf
44067 PHS398_CoverPageSupplement_1_4-1.4.pdf
44067 PHS398_ResearchPlan_1_3-1.3.pdf
44067 PHS398_Checklist_1_3-1.3.pdf
Optional forms
44067 PHS_CoverLetter_1_2-1.2.pdf
44067 PHS398_ModularBudget-1.1.pdf
44067 RR_Budget-1.1.pdf
44067 RR_SubawardBudget-1.2.pdf
Package 2
Mandatory forms
44067 RR_SF424-1.1.pdf
44067 RR_KeyPersonExpanded-1.1.pdf
44067 RR_OtherProjectInfo-1.1.pdf
44067 RR_PerformanceSite-1.1.pdf
44067 PHS398_CoverPageSupplement-1.1.pdf
44067 PHS398_ResearchPlan-1.1.pdf
44067 PHS398_Checklist-1.1.pdf
Optional forms
44067 PHS398_CoverLetter-1.1.pdf
44067 PHS398_ModularBudget-1.1.pdf
44067 RR_Budget-1.1.pdf
44067 RR_SubawardBudget-1.2.pdf
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