This grant opportunity encourages research on tumor stem cell biology to understand the molecular regulation of embryonic and adult stem cell behavior in relation to tumor formation. By focusing on the isolation and characterization of tumor stem cells from various tumors, the aim is to enhance the knowledge of malignant disease progression and potentially develop new therapeutic strategies to target tumor stem cells. Emphasis is also placed on investigating the genetic and biochemical mechanisms controlling self-renewal, asymmetric cell division, and the stem cell microenvironment for more effective cancer therapies.
Opportunity ID: 44089
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-08-165 |
| Funding Opportunity Title: | Stem Cells and Cancer (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.393 — Cancer Cause and Prevention Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | May 07, 2011 |
| Current Closing Date for Applications: | May 07, 2011 |
| Archive Date: | Jun 07, 2011 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled “Additional Information on Eligibility” for clarification) Private institutions of higher education State governments Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Hispanic-serving Institutions; Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), and the National Institute on Aging (NIA), encourages research in all aspects of tumor stem cell biology, including the molecular and biochemical regulation of embryonic and adult stem cell behavior relevant to tumor formation. Tumor stem cells are a rare population of cells that can recapitulate all the cell types represented in the original tumor. Tumor stem cells are capable of self-renewal and asymmetric cell division. These cells are putatively responsible for the transplantability and metastatic properties of tumors. This FOA intends to stimulate efforts on isolation and characterization of tumor stem cells from a large spectrum of tumors. Such studies are important in order to understand the progression of malignant diseases. They may also inspire the development of new therapeutic strategies based on specific targeting of tumor stem cells. In addition, more research is encouraged to understand the genetic and biochemical regulatory mechanisms that control the self-renewal phenotype, asymmetric cell division, and the stem cell microenvironment (or niche ). It is anticipated that the results of such research will ultimately improve the specificity and long-term effectiveness of cancer therapy. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-08-165.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009437 | Dec 05, 2008 | Feb 20, 2010 | View | |
| ADOBE-FORMS-B | Use for submissions intended for due dates of January 25, 2010 and beyond | PKG00015261 | Dec 21, 2009 | May 07, 2011 | View |
Package 1
Mandatory forms
44089 RR_SF424-1.1.pdf
44089 RR_KeyPersonExpanded-1.1.pdf
44089 RR_OtherProjectInfo-1.1.pdf
44089 RR_PerformanceSite-1.1.pdf
44089 PHS398_CoverPageSupplement-1.1.pdf
44089 PHS398_ResearchPlan-1.1.pdf
44089 PHS398_Checklist-1.1.pdf
Optional forms
44089 PHS398_CoverLetter-1.1.pdf
44089 PHS398_ModularBudget-1.1.pdf
44089 RR_Budget-1.1.pdf
44089 RR_SubawardBudget-1.2.pdf
Package 2
Mandatory forms
44089 RR_SF424_1_2-1.2.pdf
44089 PerformanceSite_1_3-1.3.pdf
44089 RR_OtherProjectInfo_1_2-1.2.pdf
44089 RR_KeyPersonExpanded_1_2-1.2.pdf
44089 PHS398_CoverPageSupplement_1_4-1.4.pdf
44089 PHS398_ResearchPlan_1_3-1.3.pdf
44089 PHS398_Checklist_1_3-1.3.pdf
Optional forms
44089 PHS_CoverLetter_1_2-1.2.pdf
44089 PHS398_ModularBudget-1.1.pdf
44089 RR_Budget-1.1.pdf
44089 RR_SubawardBudget-1.2.pdf
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