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This department is funding research to explore how glycans in the HIV-1 envelope protein influence immune responses and vaccine development. The grant aims to support collaborative efforts to investigate glycosylation’s impact on immune quality and develop innovative HIV vaccine design strategies. The ultimate goal is to develop a safe and effective vaccine that provides long-term protection against HIV, incorporating new knowledge on the crucial role of glycans in immune response activation.
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Opportunity ID: 144013
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | PA-12-105 |
| Funding Opportunity Title:: | Functional Glycomics in HIV Vaccine Design (R01) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Health |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 93.855 — Allergy, Immunology and Transplantation Research |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 2 |
| Posted Date:: | Feb 14, 2012 |
| Last Updated Date:: | Oct 19, 2012 |
| Original Closing Date for Applications:: | Jan 07, 2015 |
| Current Closing Date for Applications:: | May 07, 2013 |
| Archive Date:: | Jun 07, 2013 |
| Estimated Total Program Funding:: | |
| Award Ceiling:: | $ |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Independent school districts |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | Glycans play key roles in the transmission, antigenicity, and immunogenicity of the HIV-1 envelope protein. Glycans also modulate the immune response, playing an essential role in both innate and adaptive immunity. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate and foster multi-disciplinary investigator- initiated collaborative research to 1) investigate structural and conformational features of glycosylation that may lead to novel HIV vaccine design approaches, and 2) to elucidate the impact of differential glycosylation on the quality of the immune response to HIV. Ultimately, the discovery of a safe, effective, prophylactic vaccine that provides long-term protection from HIV infection may depend on novel approaches that incorporate new knowledge of the key role glycans play in the elicitation and maturation of broadly neutralizing antibodies and effector immune responses. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 2 | Modified Archive Date based on new Expiration Date, per NOT-AI-13-003. | Oct 19, 2012 |
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | |
| Competition ID: | ADOBE-FORMS-B2 |
| Competition Title: | ADOBE-FORMS-B2 |
| Opportunity Package ID: | PKG00097490 |
| Opening Date: | Apr 07, 2012 |
| Closing Date: | May 07, 2013 |
| Agency Contact Information:: | Grants Info |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3] |
| optional_forms |
R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2] |
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | ADOBE-FORMS-B2 | PKG00097490 | Apr 07, 2012 | May 07, 2013 | View | Grants Info | Organization Applicants |
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