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The NIEHS is offering the TaRGET I grant to support research on the impact of environmental toxicants on gene expression through chromatin structure and genomic processes. This grant aims to advance mechanistic understanding of how environmental exposures influence the establishment and maintenance of gene expression patterns and chromatin states. Researchers are encouraged to move beyond descriptive studies and explore the proteins and functional genomic elements involved in epigenetic modifications caused by exposure. Closing date for applications is Nov 19, 2012.
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Opportunity ID: 194733
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | RFA-ES-12-008 |
| Funding Opportunity Title:: | TaRGET I: Chromatin Structure, Genomics, and Transcriptional Responses to the Environment (R01) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Education |
| Category Explanation:: | |
| Expected Number of Awards:: | 5 |
| Assistance Listings Number(s):: | 93.113 — Environmental Health |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 1 |
| Posted Date:: | Aug 23, 2012 |
| Last Updated Date:: | |
| Original Closing Date for Applications:: | Nov 19, 2012 |
| Current Closing Date for Applications:: | Nov 19, 2012 |
| Archive Date:: | Dec 20, 2012 |
| Estimated Total Program Funding:: | $ 3,000,000 |
| Award Ceiling:: | $400,000 |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | Special district governments |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | In order to understand the mechanisms by which toxicants impact gene expression, it is necessary to better understand how exposure affects the proteins and processes upstream of DNA methylation and other epigenetic marks. The NIEHS has made a significant investment in research aimed at identifying epigenetic signatures of exposure, but the mechanistic studies aimed at identifying how these epigenetic marks are established are currently under-represented in our portfolio. The purpose of this FOA is to encourage research applications that will potentially move the field from descriptive and correlative studies to an enhanced mechanistic understanding of how environmental exposures affect the proteins and functional genomic elements involved in establishing and maintaining gene expression patterns and chromatin states. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | |
| Competition ID: | ADOBE-FORMS-B2 |
| Competition Title: | Adobe-Forms-B2 |
| Opportunity Package ID: | PKG00140410 |
| Opening Date: | Oct 19, 2012 |
| Closing Date: | Nov 19, 2012 |
| Agency Contact Information:: | Grants Info |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V1.2] Project/Performance Site Location(s) [V1.4] Research And Related Other Project Information [V1.3] Research And Related Senior/Key Person Profile (Expanded) [V1.2] PHS 398 Cover Page Supplement [V1.4] PHS 398 Research Plan [V1.3] PHS 398 Checklist [V1.3] |
| optional_forms |
R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.1] PHS Cover Letter [V1.2] |
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| ADOBE-FORMS-B2 | Adobe-Forms-B2 | PKG00140410 | Oct 19, 2012 | Nov 19, 2012 | View | Grants Info | Organization Applicants |
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