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The National Institutes of Health (NIH) is offering the Genomics of Gene Regulation (GGR) grant to support new initiatives in exploring genomic approaches to understanding gene networks’ regulation. This grant aims to decipher the rules governing gene network regulation and its impact on cellular function, development, and disease. Projects will focus on developing and validating models that describe sequence-based functional elements’ role in regulating genes. The emphasis is on substantial improvements in gene regulatory network model development rather than incremental advancements. The grant seeks to advance the field towards accurately predicting gene expression levels from DNA sequence data in specific cell states.
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Opportunity ID: 239354
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | RFA-HG-13-012 |
| Funding Opportunity Title:: | Genomics of Gene Regulation (U01) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Health |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 93.172 — Human Genome Research |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 1 |
| Posted Date:: | Aug 06, 2013 |
| Last Updated Date:: | |
| Original Closing Date for Applications:: | Nov 15, 2013 |
| Current Closing Date for Applications:: | Nov 15, 2013 |
| Archive Date:: | Dec 16, 2013 |
| Estimated Total Program Funding:: | $ 10,000,000 |
| Award Ceiling:: | $ |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | State governments |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | This Funding Opportunity Announcement (FOA) solicits applications to start a new initiative, the Genomics of Gene Regulation (GGR), which is intended to explore genomic approaches to understanding the role of genomic sequence in the regulation of gene networks. A long-term goal of functional genomics is to decipher the rules by which gene networks are regulated and to understand how such regulation affects cellular function, development and disease. The GGR initiative will address the genome-proximal component of the regulation of gene networks by supporting a set of demonstration projects to develop and validate models that describe how a comprehensive set of sequence-based functional elements work in concert to regulate the finite set of genes that determine a biological phenomenon, using RNA amounts, and perhaps transcript structure, as the readout. This FOA seeks to support substantial improvement in the methods for developing gene regulatory network models, rather than an incremental improvement on existing methods. This work will move the field closer to the long-term goal of reading DNA sequence and accurately predicting when and at what levels a gene is expressed, in the context of a particular cell state. These demonstration projects will be organized as a research consortium to accelerate progress through the coordination of analytical methods and functional genomic data. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | 93.172 |
| Competition ID: | FORMS-C |
| Competition Title: | Forms-C |
| Opportunity Package ID: | PKG00182491 |
| Opening Date: | Oct 15, 2013 |
| Closing Date: | Nov 15, 2013 |
| Agency Contact Information:: | eRA Commons Help Desk |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
SF424 (R & R) [V2.0] PHS 398 Research Plan [V2.0] PHS 398 Cover Page Supplement [V2.0] Research and Related Senior/Key Person Profile (Expanded) [V2.0] Research And Related Other Project Information [V1.3] Project/Performance Site Location(s) [V2.0] |
| optional_forms |
R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.3] Planned Enrollment Report [V1.0] PHS 398 Cumulative Inclusion Enrollment Report [V1.0] PHS 398 Modular Budget [V1.2] Research & Related Budget [V1.3] |
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| 93.172 | FORMS-C | Forms-C | PKG00182491 | Oct 15, 2013 | Nov 15, 2013 | View | eRA Commons Help Desk | Organization Applicants |
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