DARPA Microphysiological Systems Grant

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DARPA is offering a grant for the development of in vitro platforms using human tissue constructs to accurately predict the safety, efficacy, and pharmacokinetics of drugs and vaccines. This grant aims to support the advancement of alternative testing methods that provide authentic human responses to candidate drugs and biologics. The research should focus on creating three-dimensional constructs of human tissues to mimic physiological conditions, enabling effective assessment of efficacy, toxicity, and pharmacokinetics in a manner relevant to humans and suitable for regulatory approval. Closing date for applications is December 12, 2011.

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Opportunity ID: 122833

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General Information

Document Type:: Grants Notice
Funding Opportunity Number:: DARPA-BAA-11-73
Funding Opportunity Title:: Microphysiological Systems
Opportunity Category:: Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity:: Science and Technology and other Research and Development
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s):: 12.910 — Research and Technology Development
Cost Sharing or Matching Requirement:: No
Version:: Synopsis 2
Posted Date:: Sep 15, 2011
Last Updated Date:: Sep 15, 2011
Original Closing Date for Applications:: Dec 12, 2011
Current Closing Date for Applications:: Dec 12, 2011
Archive Date:: Jan 11, 2012
Estimated Total Program Funding::
Award Ceiling:: $
Award Floor:: $

Eligibility

Eligible Applicants:: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility”
Additional Information on Eligibility::

Additional Information

Agency Name:: DARPA – Defense Sciences Office
Description:: DARPA seeks an in vitro platform of human tissues that accurately predicts the safety, efficacy, and pharmacokinetics of drugs and vaccines before their administration to humans. Alternative testing methods that rely on isolated human cells hold the promise of authentic human responses to candidate drugs, vaccines, and biologics. Recent research has shown that three-dimensional constructs of one or more cell types are able to reproduce relatively authentic human tissue and organ physiology in an in vitro environment. As a result, DARPA seeks in vitro platforms comprised of human tissue constructs that will accurately assess efficacy, toxicity, and pharmacokinetics in a way that is relevant to humans and suitable for regulatory review. See Attached DARPA-BAA-11-73.
Link to Additional Information::
Grantor Contact Information:: If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version Modification Description Updated Date
Synopsis 2 The purpose of this Modificaiton 1 to DARPA-BAA-11-73 Microphysiological Systems is to update the Closing Date.

The following section is revised as follows:

Part One: Overview Information
Dates
Closing Date, 4:00 PM ET, December 12, 2011.

Sep 15, 2011
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

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Packages

Assistance Listings Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions Who Can Apply:
12.910 PKG00078490 Sep 15, 2011 Dec 12, 2011 View Dr. Barry Pallotta Organization and Individual Applicants

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