DARPA: Producing rBuChE in Plants Research Grant

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DARPA is offering a grant for innovative research to produce a recombinant butyrylcholinesterase (rBuChE) using Nicotiana benthamiana plants. The goal is to create a plant-based form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents, matching the pharmacokinetic profile of human butyrylcholinesterase. This funding opportunity is for basic research to establish the technical feasibility of using plant platforms for this purpose. The grant period is 12 months, aiming to advance biotechnology in defense against chemical threats.

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Opportunity ID: 144634

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General Information

Document Type:: Grants Notice
Funding Opportunity Number:: DARPA-BAA-12-31
Funding Opportunity Title:: Butyrylcholinesterase Expression in Plants
Opportunity Category:: Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity:: Science and Technology and other Research and Development
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s):: 12.910 — Research and Technology Development
Cost Sharing or Matching Requirement:: No
Version:: Synopsis 3
Posted Date:: Feb 16, 2012
Last Updated Date:: Mar 21, 2012
Original Closing Date for Applications:: Apr 26, 2012
Current Closing Date for Applications:: May 17, 2012
Archive Date:: Jul 17, 2012
Estimated Total Program Funding::
Award Ceiling:: $
Award Floor:: $

Eligibility

Eligible Applicants:: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled “Additional Information on Eligibility”
Additional Information on Eligibility::

Additional Information

Agency Name:: DARPA – Defense Sciences Office
Description:: DARPA is seeking innovative research proposals that will demonstrate the ability to produce a recombinant butyrylcholinesterase (rBuChE) using the Nicotiana benthamiana plant-based expression platform that has the same pharmacokinetic profile as a plasma-derived human butyrylcholinesterase (hBuChE) butyrylcholinesterase. The funding is intended to establish the technical precedence for the use of the plant platform to generate a rapid and scalable form of pre-exposure therapeutic bioscavenger against organophosphate nerve agents. Funding is for basic research only. The anticipated period of funding is for 12 months.
Link to Additional Information::
Grantor Contact Information:: If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version Modification Description Updated Date
Synopsis 3 Modification 2 to DARPA-BAA-12-31 is to extend the Closing Date for full proposals. See attachment DARPA-BAA-12-31 Mar 21, 2012
Synopsis 2 Modification 1 to DARPA-BAA-12-31 is to revise DARPA’s mailing address. See attached Modification 1 for details.
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

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Packages

Assistance Listings Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions Who Can Apply:
12.910 PKG00098072 Feb 16, 2012 May 17, 2012 View BAA Coordinator Organization and Individual Applicants

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