HEAL Initiative: Promoting Detection Tools for Emerging Opioid Threats (UG1 – Clinical Trial Not Allowed) by the Department of Health

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The Department of Health is offering a grant to develop tools for detecting emerging opioids like nitazenes, which are currently overlooked due to a lack of standardized methods. This grant aims to address the challenges in assessing the prevalence and health impact of new illicit drugs to enhance patient stabilization and harm reduction efforts. By supporting the creation of detection tools, this grant seeks to equip clinicians with the necessary resources to respond effectively to evolving opioid threats. Applications for this grant are welcome until February 2, 2023.

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Opportunity ID: 341849

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General Information

Document Type:: Grants Notice
Funding Opportunity Number:: RFA-DA-23-045
Funding Opportunity Title:: HEAL Initiative: Rapidly Assessing the Public Health Impact of Emerging Opioid Threats (UG1 – Clinical Trial Not Allowed)
Opportunity Category:: Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity:: Education
Category Explanation::
Expected Number of Awards::
Assistance Listings Number(s):: 93.213 — Research and Training in Complementary and Integrative Health
Cost Sharing or Matching Requirement:: No
Version:: Synopsis 2
Posted Date:: Jul 07, 2022
Last Updated Date:: Jul 25, 2022
Original Closing Date for Applications:: Feb 02, 2023
Current Closing Date for Applications:: Feb 02, 2023
Archive Date:: Mar 10, 2023
Estimated Total Program Funding::
Award Ceiling:: $
Award Floor:: $

Eligibility

Eligible Applicants:: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
Additional Information on Eligibility:: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name:: National Institutes of Health
Description:: The need to rapidly develop methods to assess the prevalence / health impact of emerging illicit drugs has never been greater. Illicit chemists are marketing potent drugs of abuse taken from deep wells of scientific and patent literature, which we can expect to continue to yield new drugs for many years. Over the last few years, fentanyl/fentalogs (fentanyl-related opioids) have flooded the illicit opioid market, which has complicated patient stabilization / harm reduction, and caused mortality rates to skyrocket. Even understanding the drugs being used is difficult due to unstandardized analytical methods, and urine test strip kit variabilities. When test strips do detect fentalogs they simply indicate fentanyl and clinicians base treatment on this homogenous grouping. However, it is unclear that the addictive or mortality risk of fentalogs are generalizable. Initially fentanyl was reported to be long-lasting and poorly antagonizable, but such reports diminished when carfentanil, an ultrapotent and long-lasting fentalog, diminished in drug supplies. Now, ultrapotent “nitazene” opioids are on the market and a lack of validated analytical protocols and standards, has meant these drugs are over-looked in most jurisdictions. Nitazene urine test strips do not yet exist and so clinicians are ill-equipped to recognize nitazenes and respond appropriately. Users certainly do not know whether nitazenes (or fentalogs) are illicit purchased drugs. This FOA promotes development and distribution of tools to detect nitazenes in the necessary range of settings needed to enable appropriately calculated responses. Additionally, this RFA builds-in funds to allow awardees to rapidly bring their discoveries and expertise to bear on the future generations of threats that are surely coming
Link to Additional Information::
Grantor Contact Information:: If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version Modification Description Updated Date
Synopsis 2 Changed title to reflect that Clinical Trials are not allowed. Jul 25, 2022
Synopsis 1 Jul 07, 2022

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:
Competition ID: FORMS-G
Competition Title: Use for due dates on or before January 24, 2023
Opportunity Package ID: PKG00275589
Opening Date: Jan 02, 2023
Closing Date: Jan 24, 2023
Agency Contact Information:: eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/
Who Can Apply:: Organization Applicants
mendatory_forms SF424 (R & R) [V5.0]
PHS 398 Cover Page Supplement [V5.0]
Research And Related Other Project Information [V1.4]
Project/Performance Site Location(s) [V4.0]
Research and Related Senior/Key Person Profile (Expanded) [V4.0]
Research & Related Budget [V3.0]
PHS 398 Research Plan [V4.0]
PHS Human Subjects and Clinical Trials Information [V3.0]
optional_forms R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V3.0]
PHS Assignment Request Form [V3.0]

Package No: 2

Assistance Listings:
Competition ID: FORMS-H
Competition Title: Use for due dates on or after January 25, 2023
Opportunity Package ID: PKG00277619
Opening Date: Jan 02, 2023
Closing Date: Feb 02, 2023
Agency Contact Information:: eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/
Who Can Apply:: Organization Applicants
mendatory_forms SF424 (R & R) [V5.0]
PHS 398 Cover Page Supplement [V5.0]
Research And Related Other Project Information [V1.4]
Project/Performance Site Location(s) [V4.0]
Research and Related Senior/Key Person Profile (Expanded) [V4.0]
Research & Related Budget [V3.0]
PHS 398 Research Plan [V5.0]
PHS Human Subjects and Clinical Trials Information [V3.0]
optional_forms R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V3.0]
PHS Assignment Request Form [V3.0]

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Packages

Assistance Listings Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions Who Can Apply:
FORMS-G Use for due dates on or before January 24, 2023 PKG00275589 Jan 02, 2023 Jan 24, 2023 View eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ Organization Applicants

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Assistance Listings Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions Who Can Apply:
FORMS-H Use for due dates on or after January 25, 2023 PKG00277619 Jan 02, 2023 Feb 02, 2023 View eRA Service Desk Monday to Friday 7 am to 8 pm ET http://grants.nih.gov/support/ Organization Applicants

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