This department is offering the Biosignatures of Chronic Drug Exposure Grant (R21) to support high-risk projects focusing on identifying peripheral biological indicators, not associated with the central nervous system, to monitor changes in the brain due to drug exposure. The grant aims to identify suitable biomaterials and molecules for developing screening assays using animal models. The National Institute on Drug Abuse acknowledges the risky nature of the project and will award $2,000,000 for 5-7 grants. The closing date for submissions is Jan 27, 2009.
Opportunity ID: 42949
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | RFA-DA-09-022 |
| Funding Opportunity Title: | Biosignatures of Chronic Drug Exposure (R21) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.279 — Drug Abuse and Addiction Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Oct 01, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | Jan 27, 2009 |
| Current Closing Date for Applications: | Jan 27, 2009 |
| Archive Date: | Feb 27, 2009 |
| Estimated Total Program Funding: | $2,000,000 |
| Award Ceiling: | $200,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Others (see text field entitled “Additional Information on Eligibility” for clarification) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Private institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Native American tribal governments (Federally recognized) Small businesses |
| Additional Information on Eligibility: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -Purpose. In relation to this FOA, biosignatures are defined as biological indicators obtainable through assays, which can be used to ascertain facts about an individual’s past exposure to drugs of abuse. Biosignature could be comprised of more than one biomarker. The total number of biomarkers must be reasonably limited to address the developability of the screening assay. This FOA would support high risk projects to search for peripheral, not associated with the central nervous system, biosignatures (not drug or drug metabolites) that could serve as surrogates to monitor changes that are taking place in the brain in response to illicit and licit drug exposure, withdrawal or relapse. These projects are intended to be feasibility projects using animal models only to identify appropriate clinically accessible biomaterial (e.g., blood, lymphocytes, bladder epithelial cells, stem cells) and to identify the best class or classes of molecules (proteins, peptides, RNA, miRNA, etc.) suitable for assay development . These feasibility projects are intended to address technical issues such as sensitivity and signal-to-noise ratio, in addition to predictive validity. . -Mechanism of Support. This FOA will utilize the R21 grant mechanism, as The National Institute on Drug Abuse recognizes the high risk nature of this project. -Funds Available and Anticipated Number of Awards. The total amount of funding that the NIDA expects to award through this announcement is $2,000,000 for an anticipated 5-7 awards. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-09-022.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| 93.279 | ADOBE-FORMS-A | Adobe-Forms-A | PKG00009582 | Dec 27, 2008 | Jan 27, 2009 | View |
Package 1
Mandatory forms
42949 RR_SF424-1.1.pdf
42949 RR_KeyPersonExpanded-1.1.pdf
42949 RR_OtherProjectInfo-1.1.pdf
42949 RR_PerformanceSite-1.1.pdf
42949 PHS398_CoverPageSupplement-1.1.pdf
42949 PHS398_ResearchPlan-1.1.pdf
42949 PHS398_Checklist-1.1.pdf
Optional forms
42949 PHS398_CoverLetter-1.1.pdf
42949 PHS398_ModularBudget-1.1.pdf
42949 RR_Budget-1.1.pdf
42949 RR_SubawardBudget-1.2.pdf
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