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The National Institutes of Health is offering a grant to establish research centers focused on studying botanicals found in dietary supplements and their impact on human health. The grant aims to support the development of preclinical data necessary for designing rigorous clinical trials, with a focus on understanding the mechanisms of action of botanicals traditionally used for health maintenance. Research will utilize transdisciplinary approaches and various models to explore the interactions between botanical products and human biology. Applications must integrate expertise in disciplines such as phytochemistry and botany, emphasizing basic and preclinical research with potential limited human subjects research aims.
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Opportunity ID: 248914
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | RFA-OD-14-001 |
| Funding Opportunity Title:: | Botanical Dietary Supplement Research Centers (P50) |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Health |
| Category Explanation:: | |
| Expected Number of Awards:: | |
| Assistance Listings Number(s):: | 93.213 — Research and Training in Complementary and Alternative Medicine |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 1 |
| Posted Date:: | Dec 05, 2013 |
| Last Updated Date:: | |
| Original Closing Date for Applications:: | Jun 06, 2014 |
| Current Closing Date for Applications:: | Jun 06, 2014 |
| Archive Date:: | Jul 07, 2014 |
| Estimated Total Program Funding:: | |
| Award Ceiling:: | $1,250,000 |
| Award Floor:: | $ |
Eligibility
| Eligible Applicants:: | City or township governments |
| Additional Information on Eligibility:: | Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name:: | National Institutes of Health |
| Description:: | This Funding Opportunity Announcement (FOA) invites applications to support research centers to develop and apply cutting-edge, transdisciplinary approaches to the study of botanicals with relevance to human health, that are found as ingredients in dietary supplements. These centers are expected to synergistically integrate a range of relevant disciplines (e.g., phytochemistry, botany, and expertise utilizing models ranging from in silico through in vitro to in vivo) to conduct innovative research to elucidate the interactions between complex botanical products and human biology. The long-term goal of this program is to support development of the preclinical data required for optimal design of rigorous, definitive clinical research on complex botanical products. Given the extensive resources required for clinical research it is critical that clinical trials of botanicals be supported by solid and extensive relevant preclinical data, especially with respect to mechanisms of action, optimal formulations and dosing, for example. Therefore the focus of these Centers will be on basic and preclinical research. The focus of this FOA is on research on the mechanisms of action of botanicals traditionally used for health maintenance, or on botanicals with strong evidence of promise for improving objective, quantitative measures of organism resilience. Use of relevant vertebrate and invertebrate models is strongly encouraged. A strictly limited number of human subjects research aims, designed to interrogate, e.g., in vivo mechanism(s) of action, safety, pharmacokinetics, or bases of individual differences in metabolism or response, may be included. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| 93.213 | FORMS-C | Forms-C | PKG00190711 | May 06, 2014 | Jun 06, 2014 | View | eRA Commons Help Desk | Organization Applicants |
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