The National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Cancer Institute (NCI), and Office of Dietary Supplements (ODS) of the National Institutes of Health (NIH) are offering grants to institutions/organizations to investigate the molecular and biochemical mechanisms underlying alcohol-related cancers. Research will focus on understanding the impact of chronic alcohol consumption on cancers of organs like the oral cavity, liver, and breast, exploring factors such as acetaldehyde, CYP2E1, VEGF, immune function, and metabolism of key nutrients. This grant opportunity utilizes the R01 mechanism and aims to support innovative research in this area.
Opportunity ID: 43765
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-07-069 |
| Funding Opportunity Title: | Mechanisms of Alcohol-Associated Cancers (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Apr 05, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education County governments Native American tribal governments (Federally recognized) City or township governments Special district governments Independent school districts State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS), National Institutes of Health (NIH), solicits grant applications from institutions/organizations that propose to employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms by which chronic alcohol consumption leads to the development of cancers of various organs such as oral cavity, pharynx, larynx, esophagus, stomach, large intestine, liver, and breast. This includes investigating roles of various factors such as acetaldehyde, cytochrome P450 2E1 (CYP2E1), vascular endothelial growth factor (VEGF), impaired immune function, and alcohol-induced impaired metabolism of s-adenosylmethionine (SAMe), folate, betaine, iron, and vitamin A. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-06-270, that solicits applications under the Exploratory/Developmental (R21) grant mechanism. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-07-069.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009113 | Dec 05, 2008 | Mar 06, 2009 | View |
Package 1
Mandatory forms
43765 RR_SF424-1.1.pdf
43765 RR_KeyPersonExpanded-1.1.pdf
43765 RR_OtherProjectInfo-1.1.pdf
43765 RR_PerformanceSite-1.1.pdf
43765 PHS398_CoverPageSupplement-1.1.pdf
43765 PHS398_ResearchPlan-1.1.pdf
43765 PHS398_Checklist-1.1.pdf
Optional forms
43765 PHS398_CoverLetter-1.1.pdf
43765 PHS398_ModularBudget-1.1.pdf
43765 RR_Budget-1.1.pdf
43765 RR_SubawardBudget-1.2.pdf
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