This joint grant offered by National Institute of Alcohol Abuse and Alcoholism (NIAAA) and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) aims to support research on the impact of diet, dietary factors, and supplements on epigenetic processes in cancer prevention. The grant encourages collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties, focusing on DNA methylation, histone modification, and other key epigenetic events in cancer processes. Specifically interested in exploring the effects of chronic alcohol consumption on DNA methylation levels and the impact of epigenetics on cell division and differentiation in the gastrointestinal tract. Utilizing the R01 grant mechanism.
Opportunity ID: 43833
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-07-175 |
| Funding Opportunity Title: | Diet, Epigenetic Events, and Cancer Prevention (R01) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Food and Nutrition Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.273 — Alcohol Research Programs |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Oct 02, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | – |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities City or township governments State governments Small businesses Public and State controlled institutions of higher education Special district governments For profit organizations other than small businesses |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -Purpose. The aim of this Funding Opportunity Announcement (FOA) is to promote clinical and preclinical research to determine how diet and dietary factors, including dietary supplements, impact DNA methylation, histone posttranslational modification, and other epigenetic processes involved in cancer prevention and development. Another important aim of this FOA is to encourage collaborations between nutrition and epigenetic experts to study bioactive food components with cancer-preventative properties and to examine key epigenetic events in cancer processes (e.g., carcinogen metabolism, cell division, differentiation, and apoptosis) in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors. The National Institute of Alcohol Abuse and Alcoholism (NIAAA) is specifically interested in receiving applications that examine the impact(s) of chronic alcohol consumption on levels of S-adenosylmethionine (SAM), betaine, and folate, and possible associations with DNA methylation and cancer. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is particularly interested in receiving applications that address normal and neoplastic conditions focusing on the impact of epigenetics on cell division, differentiation, and/or apoptosis in the gastrointestinal (GI) tract and related organs. -Mechanism of Support. This FOA will utilize the R01 grant mechanism and runs in parallel with two FOAs of identical scientific scope PA-06-414, which solicits applications using the NIH small (R03) grant mechanism, and PA-06-413, which solicits applications using the NIH exploratory/developmental (R21) grant mechanism. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-07-175.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009181 | Dec 05, 2008 | Sep 07, 2009 | View |
Package 1
Mandatory forms
43833 RR_SF424-1.1.pdf
43833 RR_KeyPersonExpanded-1.1.pdf
43833 RR_OtherProjectInfo-1.1.pdf
43833 RR_PerformanceSite-1.1.pdf
43833 PHS398_CoverPageSupplement-1.1.pdf
43833 PHS398_ResearchPlan-1.1.pdf
43833 PHS398_Checklist-1.1.pdf
Optional forms
43833 PHS398_CoverLetter-1.1.pdf
43833 PHS398_ModularBudget-1.1.pdf
43833 RR_Budget-1.1.pdf
43833 RR_SubawardBudget-1.2.pdf
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