The National Institute of Dental and Craniofacial Research (NIDCR) and the National Cancer Institute (NCI) are offering a Small Research Grant (R03) for projects exploring the pathophysiological mechanisms behind osteonecrosis of the jaw (ONJ) linked to bisphosphonate use. The research should focus on understanding bone healing impairments and ONJ development. This grant supports pilot and developmental research aimed at laying the foundation for future Individual Research Project Grant (R01) applications, especially for early-career investigators. The R03 does not renew and aligns with related NIH grant mechanisms for ONJ research.
Opportunity ID: 43722
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-502 |
| Funding Opportunity Title: | Pathophysiology of Bisphosphonates-associated Osteonecrosis of the Jaw (R03) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | Sep 07, 2009 Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Oct 07, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $50,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Native American tribal governments (Federally recognized) Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct. Projects must focus on studying oral bone homeostasis, healing response or repair capacity in the presence or absence of bisphosphonates rather than on the broad effects of bisphosphonates on bone quality. Projects that examine the effects of bisphosphonates on skeletal biology will not be considered unless the experimental design includes analysis of oral bones. Projects may study the effects of bisphosphonates on other physiological processes such as angiogenesis but only within the context that perturbation of these processes may compromise oral bone homeostasis and healing. Projects that examine the pharmacology of bisphosphonates will be considered non-responsive unless the projects propose to test whether genetic variations alter the pharmacokinetics or pharmacodynamics of bisphosphonates. Epidemiological studies are non-responsive. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -The National Institute of Dental and Craniofacial Research (NIDCR) and the National Cancer Institute (NCI) invite Small Research Grant (R03) applications for research projects focusing on basic and translational studies of osteonecrosis of the jaw (ONJ), an oral complication associated with bisphosphonate use. Projects should aim to identify and characterize the pathophysiological mechanisms that lead to impaired bone healing and the development of ONJ. -This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with two FOAs of identical scientific scope, PA-06-500 that solicits applications under the NIH Individual Research Project Grant (R01) mechanism, and PA-06-501 that solicits applications under the NIH Exploratory/Developmental Grant (R21) mechanism. -This R03 is intended to support pilot and developmental research that is likely to lead to a subsequent Individual Research Project Grant (R01) application from scientists who are in the early stages of establishing an independent research career. The R03 is not renewable. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-502.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Archive Date has been updated due to Expiration/Closing Date change. | – | |
| Dec 05, 2008 |
DISPLAYING: Synopsis 2
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-502 |
| Funding Opportunity Title: | Pathophysiology of Bisphosphonates-associated Osteonecrosis of the Jaw (R03) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 2 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Current Closing Date for Applications: | Sep 07, 2009 Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Oct 07, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $50,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | County governments Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Small businesses Native American tribal governments (Federally recognized) Private institutions of higher education Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct. Projects must focus on studying oral bone homeostasis, healing response or repair capacity in the presence or absence of bisphosphonates rather than on the broad effects of bisphosphonates on bone quality. Projects that examine the effects of bisphosphonates on skeletal biology will not be considered unless the experimental design includes analysis of oral bones. Projects may study the effects of bisphosphonates on other physiological processes such as angiogenesis but only within the context that perturbation of these processes may compromise oral bone homeostasis and healing. Projects that examine the pharmacology of bisphosphonates will be considered non-responsive unless the projects propose to test whether genetic variations alter the pharmacokinetics or pharmacodynamics of bisphosphonates. Epidemiological studies are non-responsive. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -The National Institute of Dental and Craniofacial Research (NIDCR) and the National Cancer Institute (NCI) invite Small Research Grant (R03) applications for research projects focusing on basic and translational studies of osteonecrosis of the jaw (ONJ), an oral complication associated with bisphosphonate use. Projects should aim to identify and characterize the pathophysiological mechanisms that lead to impaired bone healing and the development of ONJ. -This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with two FOAs of identical scientific scope, PA-06-500 that solicits applications under the NIH Individual Research Project Grant (R01) mechanism, and PA-06-501 that solicits applications under the NIH Exploratory/Developmental Grant (R21) mechanism. -This R03 is intended to support pilot and developmental research that is likely to lead to a subsequent Individual Research Project Grant (R01) application from scientists who are in the early stages of establishing an independent research career. The R03 is not renewable. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-502.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
DISPLAYING: Synopsis 1
General Information
| Document Type: | Grants Notice |
| Funding Opportunity Number: | PA-06-502 |
| Funding Opportunity Title: | Pathophysiology of Bisphosphonates-associated Osteonecrosis of the Jaw (R03) |
| Opportunity Category: | Discretionary |
| Opportunity Category Explanation: | – |
| Funding Instrument Type: | Grant |
| Category of Funding Activity: | Education Health |
| Category Explanation: | – |
| Expected Number of Awards: | – |
| Assistance Listings: | 93.121 — Oral Diseases and Disorders Research |
| Cost Sharing or Matching Requirement: | No |
| Version: | Synopsis 1 |
| Posted Date: | Dec 05, 2008 |
| Last Updated Date: | – |
| Original Closing Date for Applications: | – |
| Current Closing Date for Applications: | – Multiple Receipt Dates – See Link to Full Announcement for details. |
| Archive Date: | Aug 01, 2009 |
| Estimated Total Program Funding: | – |
| Award Ceiling: | $50,000 |
| Award Floor: | – |
Eligibility
| Eligible Applicants: | Private institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses State governments Independent school districts Others (see text field entitled “Additional Information on Eligibility” for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments Native American tribal governments (Federally recognized) Small businesses |
| Additional Information on Eligibility: | Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith-based or community-based organizations can apply. Applicants may submit more than one application, provided each application is scientifically distinct. Projects must focus on studying oral bone homeostasis, healing response or repair capacity in the presence or absence of bisphosphonates rather than on the broad effects of bisphosphonates on bone quality. Projects that examine the effects of bisphosphonates on skeletal biology will not be considered unless the experimental design includes analysis of oral bones. Projects may study the effects of bisphosphonates on other physiological processes such as angiogenesis but only within the context that perturbation of these processes may compromise oral bone homeostasis and healing. Projects that examine the pharmacology of bisphosphonates will be considered non-responsive unless the projects propose to test whether genetic variations alter the pharmacokinetics or pharmacodynamics of bisphosphonates. Epidemiological studies are non-responsive. |
Additional Information
| Agency Name: | National Institutes of Health |
| Description: | -The National Institute of Dental and Craniofacial Research (NIDCR) and the National Cancer Institute (NCI) invite Small Research Grant (R03) applications for research projects focusing on basic and translational studies of osteonecrosis of the jaw (ONJ), an oral complication associated with bisphosphonate use. Projects should aim to identify and characterize the pathophysiological mechanisms that lead to impaired bone healing and the development of ONJ. -This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with two FOAs of identical scientific scope, PA-06-500 that solicits applications under the NIH Individual Research Project Grant (R01) mechanism, and PA-06-501 that solicits applications under the NIH Exploratory/Developmental Grant (R21) mechanism. -This R03 is intended to support pilot and developmental research that is likely to lead to a subsequent Individual Research Project Grant (R01) application from scientists who are in the early stages of establishing an independent research career. The R03 is not renewable. |
| Link to Additional Information: | http://grants.nih.gov/grants/guide/pa-files/PA-06-502.html |
| Grantor Contact Information: | If you have difficulty accessing the full announcement electronically, please contact:
NIH OER Webmaster
FBOWebmaster@OD.NIH.GOV Email:FBOWebmaster@OD.NIH.GOV |
Related Documents
There are no related documents on this grant.
Packages
| Agency Contact Information: | NIH OER Webmaster FBOWebmaster@OD.NIH.GOV Email: FBOWebmaster@OD.NIH.GOV |
| Who Can Apply: | Organization Applicants |
| Assistance Listing Number | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions |
|---|---|---|---|---|---|---|
| ADOBE-FORMS-A | Adobe-Forms-A | PKG00009070 | Dec 05, 2008 | Sep 07, 2009 | View |
Package 1
Mandatory forms
43722 RR_SF424-1.1.pdf
43722 RR_OtherProjectInfo-1.1.pdf
43722 RR_PerformanceSite-1.1.pdf
43722 PHS398_CoverPageSupplement-1.1.pdf
43722 PHS398_ResearchPlan-1.1.pdf
43722 PHS398_Checklist-1.1.pdf
Optional forms
43722 PHS398_CoverLetter-1.1.pdf
43722 PHS398_ModularBudget-1.1.pdf
43722 RR_Budget-1.1.pdf
43722 RR_SubawardBudget-1.2.pdf
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