NIEHS: Investigating Chromatin Structure and Genomic Responses to Environmental Exposures (R01)

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The NIEHS is offering the TaRGET I grant to support research on the impact of environmental toxicants on gene expression through chromatin structure and genomic processes. This grant aims to advance mechanistic understanding of how environmental exposures influence the establishment and maintenance of gene expression patterns and chromatin states. Researchers are encouraged to move beyond descriptive studies and explore the proteins and functional genomic elements involved in epigenetic modifications caused by exposure. Closing date for applications is Nov 19, 2012.

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Opportunity ID: 194733

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General Information

Document Type:: Grants Notice
Funding Opportunity Number:: RFA-ES-12-008
Funding Opportunity Title:: TaRGET I: Chromatin Structure, Genomics, and Transcriptional Responses to the Environment (R01)
Opportunity Category:: Discretionary
Opportunity Category Explanation::
Funding Instrument Type::
Category of Funding Activity:: Education
Category Explanation::
Expected Number of Awards:: 5
Assistance Listings Number(s):: 93.113 — Environmental Health
Cost Sharing or Matching Requirement:: No
Version:: Synopsis 1
Posted Date:: Aug 23, 2012
Last Updated Date::
Original Closing Date for Applications:: Nov 19, 2012
Current Closing Date for Applications:: Nov 19, 2012
Archive Date:: Dec 20, 2012
Estimated Total Program Funding:: $ 3,000,000
Award Ceiling:: $400,000
Award Floor:: $

Eligibility

Eligible Applicants:: Special district governments
Additional Information on Eligibility:: Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name:: National Institutes of Health
Description:: In order to understand the mechanisms by which toxicants impact gene expression, it is necessary to better understand how exposure affects the proteins and processes upstream of DNA methylation and other epigenetic marks. The NIEHS has made a significant investment in research aimed at identifying epigenetic signatures of exposure, but the mechanistic studies aimed at identifying how these epigenetic marks are established are currently under-represented in our portfolio. The purpose of this FOA is to encourage research applications that will potentially move the field from descriptive and correlative studies to an enhanced mechanistic understanding of how environmental exposures affect the proteins and functional genomic elements involved in establishing and maintaining gene expression patterns and chromatin states.
Link to Additional Information::
Grantor Contact Information:: If you have difficulty accessing the full announcement electronically, please contact:

Version History

Version Modification Description Updated Date
Synopsis 1

Package Status

Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:

Package No: 1

Assistance Listings:
Competition ID: ADOBE-FORMS-B2
Competition Title: Adobe-Forms-B2
Opportunity Package ID: PKG00140410
Opening Date: Oct 19, 2012
Closing Date: Nov 19, 2012
Agency Contact Information:: Grants Info
Who Can Apply:: Organization Applicants
mendatory_forms SF424 (R & R) [V1.2]
Project/Performance Site Location(s) [V1.4]
Research And Related Other Project Information [V1.3]
Research And Related Senior/Key Person Profile (Expanded) [V1.2]
PHS 398 Cover Page Supplement [V1.4]
PHS 398 Research Plan [V1.3]
PHS 398 Checklist [V1.3]
optional_forms R & R Subaward Budget Attachment(s) Form 5 YR 30 ATT [V1.2]
PHS 398 Modular Budget [V1.2]
Research & Related Budget [V1.1]
PHS Cover Letter [V1.2]

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Packages

Assistance Listings Competition ID Competition Title Opportunity Package ID Opening Date Closing Date Actions Who Can Apply:
ADOBE-FORMS-B2 Adobe-Forms-B2 PKG00140410 Oct 19, 2012 Nov 19, 2012 View Grants Info Organization Applicants

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