PA-23-317: NIH Funding for Expanding Existing Single Project Research Grants

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The National Institutes of Health (NIH) has announced a funding opportunity, PA-23-317, aimed at supporting competing revisions to existing NIH single project research grants and cooperative agreements. This discretionary funding instrument spans a wide range of categories, including education, health, and social services, reflecting the diverse nature of NIH-funded research. The opportunity encompasses various research areas, such as human genome research, mental health, cancer detection, and child health and development, among others.

Eligible applicants include a broad spectrum of entities, ranging from educational institutions, government bodies, non-profits, and small businesses, to special district governments and Native American tribal organizations. The primary goal of this funding opportunity is to allow for the expansion of current projects and programs within the awarding NIH Institute or Center, as identified in the competitive revision Notice of Special Interest (NOSI). Applications for these revisions will undergo rigorous scientific and technical merit evaluation by appropriate review groups in accordance with NIH peer review policies and procedures. This initiative represents a significant investment by the NIH in enhancing and broadening the scope of ongoing research projects, contributing to the advancement of knowledge and innovation in critical areas of public health. The closing date for applications is set for January 27, 2026, providing a substantial time frame for researchers to develop and submit their proposals for expanding the impact of their existing projects.

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Opportunity ID: 351124

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General Information

Document Type: Grants Notice
Funding Opportunity Number: PA-23-317
Funding Opportunity Title: Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)
Opportunity Category: Discretionary
Opportunity Category Explanation:
Funding Instrument Type: Grant
Category of Funding Activity: Education
Health
Income Security and Social Services
Category Explanation:
Expected Number of Awards:
CFDA Number(s): 93.172 — Human Genome Research
93.213 — Research and Training in Complementary and Integrative Health
93.242 — Mental Health Research Grants
93.273 — Alcohol Research Programs
93.279 — Drug Abuse and Addiction Research Programs
93.307 — Minority Health and Health Disparities Research
93.310 — Trans-NIH Research Support
93.350 — National Center for Advancing Translational Sciences
93.394 — Cancer Detection and Diagnosis Research
93.865 — Child Health and Human Development Extramural Research
Cost Sharing or Matching Requirement: No
Version: Synopsis 1
Posted Date: Nov 24, 2023
Last Updated Date: Nov 24, 2023
Original Closing Date for Applications: Jan 27, 2026
Current Closing Date for Applications: Jan 27, 2026
Archive Date: Dec 29, 2026
Estimated Total Program Funding:
Award Ceiling: $
Award Floor: $

Eligibility

Eligible Applicants: Private institutions of higher education
For profit organizations other than small businesses
State governments
Public housing authorities/Indian housing authorities
Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
County governments
Special district governments
Native American tribal governments (Federally recognized)
Others (see text field entitled “Additional Information on Eligibility” for clarification)
City or township governments
Native American tribal organizations (other than Federally recognized tribal governments)
Independent school districts
Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
Public and State controlled institutions of higher education
Small businesses
Additional Information on Eligibility: Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Additional Information

Agency Name: National Institutes of Health
Description: The National Institutes of Health (NIH) hereby notifies NIH award recipients that funds may be available for revision applications to support the expansion of existing projects and/or programs within the awarding IC identified in the competitive revision Notice of Special Interest (NOSI). Applications for Revisions will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s), in accordance with NIH peer review policy and procedures, using the stated review criteria. Only applications submitted in response to a NOSI published by an NIH Institute or Center will be allowed to apply to this NOFO.
Link to Additional Information: https://grants.nih.gov/grants/guide/pa-files/PA-23-317.html
Grantor Contact Information: If you have difficulty accessing the full announcement electronically, please contact:

NIH Grants Information
grantsinfo@nih.gov

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