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The U.S. Environmental Protection Agency (EPA) is offering a grant through its Science to Achieve Results (STAR) program for research centers to develop organotypic culture models (OCMs) for predictive toxicology. The aim is to create 3D in vitro models that mimic in vivo tissue architecture to study the toxic effects of chemical substances. The centers will focus on crafting OCMs that replicate key features of cellular organization, communication, cell-matrix interactions, and physiology. The goal is to enhance translational research in predictive toxicology, supporting medium to high throughput screening and high-content screening methodologies. Human cell lines, if used, should be existing or derived from available sources to comply with human subjects regulations set by the EPA.
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Opportunity ID: 243614
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General Information
| Document Type:: | Grants Notice |
| Funding Opportunity Number:: | EPA-G2013-STAR-L1 |
| Funding Opportunity Title:: | Organotypic Culture Models for Predictive Toxicology Center |
| Opportunity Category:: | Discretionary |
| Opportunity Category Explanation:: | CategoryExplanation |
| Funding Instrument Type:: | |
| Category of Funding Activity:: | Environment |
| Category Explanation:: | |
| Expected Number of Awards:: | 3 |
| Assistance Listings Number(s):: | 66.509 — Science To Achieve Results (STAR) Research Program |
| Cost Sharing or Matching Requirement:: | No |
| Version:: | Synopsis 1 |
| Posted Date:: | Sep 24, 2013 |
| Last Updated Date:: | |
| Original Closing Date for Applications:: | Jan 23, 2014 |
| Current Closing Date for Applications:: | Jan 23, 2014 |
| Archive Date:: | Feb 22, 2014 |
| Estimated Total Program Funding:: | $ 18,000,000 |
| Award Ceiling:: | $6,000,000 |
| Award Floor:: | $0 |
Eligibility
| Eligible Applicants:: | Others (see text field entitled “Additional Information on Eligibility” for clarification) |
| Additional Information on Eligibility:: | See Section III of the announcement for additional eligibility information. |
Additional Information
| Agency Name:: | Environmental Protection Agency |
| Description:: | The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications for research centers to investigate toxic effects of chemical substances in three-dimensional (3D) in vitro models, hereafter referred to as organotypic culture models (OCMs). OCMs are tissue culture models that mimic in vivo tissue architecture through interactions of heterotypic cell types (e.g., epithelium-stroma) and extracellular matrices (ECM). They can be established from isolated cells or from tissue fragments harvested in vivo, and will bridge the gap between conventional monolayer cell cultures and whole-animal systems.
EPA is interested in the potential application of OCMs that mimic complex cell arrangements and physiologies, scalable from mid to higher throughput screening (HTS), and high-content screening (HCS) approaches. This solicitation seeks the formation of research centers that will guide the development and evaluation of OCMs that will accelerate translational research in predictive toxicology. Three dimensional tissue models may, for example, utilize animal cells combined with mechanical scaffolds or microfluidics devices. Under this solicitation, the successful applicant will lead a Center to craft OCMs that can recapitulate critical features of in vivo cellular organization and communication, cell-matrix interplay, morphogenetic processes and differentiation, physiology and chemical metabolism. Measures of success or progress should be described toward the application of OCMs for computational toxicology and reconstructing in vivo responses to environmental chemicals and nanomaterials to improve environmental health protection. As such, the OCMs should be scalable in support of medium to high throughput strategies or high-dimensional quantitative data collection, such as high content imaging, that respond to questions relevant to chemical risk assessment and management. For applications using human cells, it is preferred that the cells are already available or derive from available cell lines. Under EPA Regulation 40 CFR Part 26 (Protection of Human Subjects), using pre-existing human cell lines is not considered human subjects research. |
| Link to Additional Information:: | |
| Grantor Contact Information:: | If you have difficulty accessing the full announcement electronically, please contact: |
Version History
| Version | Modification Description | Updated Date |
|---|---|---|
| Synopsis 1 |
Package Status
Below are CLOSED Opportunity Package(s) no longer available for this Funding Opportunity:
Package No: 1
| Assistance Listings: | 66.509 |
| Competition ID: | NONE |
| Competition Title: | None |
| Opportunity Package ID: | PKG00185971 |
| Opening Date: | Sep 24, 2013 |
| Closing Date: | Jan 23, 2014 |
| Agency Contact Information:: | Technical Contact: Barbara Klieforth, Phone: 703-347-8044, Email: klieforth.barbara@epa.gov; |
| Who Can Apply:: | Organization Applicants |
| mendatory_forms |
Application for Federal Assistance (SF-424) [V2.1] EPA Form 4700-4 [V2.1] Project Narrative Attachment Form [V1.1] EPA KEY CONTACTS FORM [V1.1] Grants.gov Lobbying Form [V1.1] Budget Information for Non-Construction Programs (SF-424A) [V1.0] Assurances for Non-Construction Programs (SF-424B) [V1.1] |
| optional_forms |
Other Attachments Form [V1.1] Disclosure of Lobbying Activities (SF-LLL) [V1.1] |
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Packages
| Assistance Listings | Competition ID | Competition Title | Opportunity Package ID | Opening Date | Closing Date | Actions | Who Can Apply: | |
|---|---|---|---|---|---|---|---|---|
| 66.509 | NONE | None | PKG00185971 | Sep 24, 2013 | Jan 23, 2014 | View | Technical Contact: Barbara Klieforth, Phone: 703-347-8044, Email: klieforth.barbara@epa.gov; | Organization Applicants |
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